RuntimeTrim must be launched with arguments providing paths to the build output of any project that contains the runtimes folder. For example, if you're running Linux and you're trying to trim the runtimes folder off Nitrocid's build output folder (/home/user/ksbin), you'd be executing RuntimeTrim like this:
$ dotnet RuntimeTrim.dll /home/user/ksbin
Once done, you'll find that the build output is now significantly smaller than before, depending on how many library files are there in the runtimes folder.